Infeksi Bakteri Gram Negatif di ICU Anak: epidemiologi, manajemen antibiotik dan pencegahan
Sari
Rumah sakit dan unit perawatan intensif (ICU) merupakan breeding ground atau tempat
berkembangnya bakteri yang resisten/multiresisten antibiotik, disebabkan penggunaan
alat invasif, kontak yang sering antara staf rumah sakit dengan pasien sehingga
memudahkan terjadi transmisi infeksi, intensitas penggunaan antibiotik yang tinggi serta
penggunaan antibiotik empiris yang berlebihan. Hal tersebut terjadi karena pasien yang
dirawat di ICU pada umumnya menderita penyakit berat dan dalam kondisi
imunokompromais.1,2
Bakteri Gram negatif mempunyai tingkat resistensi tinggi karena mempunyai mekanisme
resistensi yang multipel. Mekanisme resistensi bakteri Gram negatif terhadap antibiotik
b laktam, terutama disebabkan karena bakteri Gram negatif menghasilkan enzim b
laktamase. Berdasarkan hal tersebut, dapat dipastikan bahwa infeksi oleh bakteri Gram
negatif merupakan ancaman, terutama pada pasien imunokompromais
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DOI: http://dx.doi.org/10.14238/sp6.1.2004.32-5
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