Tata laksana Sindrom Nefrotik Kelainan Minimal pada Anak
Sari
Sindrom nefrotik kelainan minimal (SNKM) berdampak pada kesehatan fisik anak serta
mental anak dan orang tua karena penyakit ini sering relaps, pengobatan lama, dan
toksisitas obat yang serius. Pengobatan yang tidak adekuat potensial membahayakan
hidup anak karena infeksi sekunder dan dapat menyebabkan tromboemboli, kelainan
lipid, dan malnutrisi. Tata laksana SNKM meliputi tata laksana suportif, tata laksana
komplikasi, dan tata laksana spesifik dengan obat imunosupresif untuk induksi dan
mempertahankan remisi tanpa toksisitas obat yang serius. Sampai saat ini, kortikosteroid
masih merupakan pilihan pertama pada anak dengan SNKM dan obat imunosupresif
lain digunakan bila tidak respons dengan pengobatan standar kortikosteroid atau pada
relaps frekuen atau dependen steroid. Pemberian kortikosteroid sebaiknya tidak segera
dimulai setelah onset gejala karena remisi spontan dapat terjadi pada 5% kasus SNKM
kecuali kalau edema menetap atau gejala berat pada onset awal.
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DOI: http://dx.doi.org/10.14238/sp8.1.2006.60-8
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