Peran Eritropoetin pada Anemia Prematuritas

I Nyoman Sartika, Wayan Retayasa, Made Kardana, Ida Bagus Mudita

Sari


Eritropoetin merupakan molekul glikoprotein yang terdiri dari 165 asam amino dan 4 gugus karbohidrat
dengan berat molekul sekitar 34 k dalton. Peran eritropoetin dalam produksi sel darah merah melalui
meningkatkan survival, proliferasi dan diferensiasi dari progenitor eritroid pada sumsum tulang. Eritropoetin
berikatan dengan reseptor selanjutnya terjadi aktivasi ras/mitogen intraselular yang berperan dalam proliferasi
sel. Regulasi produksi eritropoetin adalah peran dari hypoxia-inducible transcription factor-1 (HIF-1). Pada
bayi yang lahir prematur terjadi penurunan kadar Hb yang berlebihan dibandingkan dengan bayi cukup
bulan. Banyak faktor yang mempengaruhi anemia prematuritas, salah satu di antaranya adalah kurang respon
eritropoetin terhadap penurunan kadar Hb. Penggunaan eritropoetin rekombinan mengurangi frekuensi
transfusi darah dan meningkatkan retikulosit dengan cepat. Eritropoetin rekombinan belum merupakan
standar pengobatan anemia prematuritas secara universal


Kata Kunci


eritropoetin; anemia; bayi prematur

Teks Lengkap:

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Referensi


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DOI: http://dx.doi.org/10.14238/sp9.6.2008.375-80

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