Abnormalitas Koagulasi sebagai Indikator Keparahan Infeksi Dengue pada Anak: Studi Kohort Retrospektif
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Latar belakang. Infeksi dengue merupakan masalah kesehatan global yang signifikan pada anak-anak, dengan gangguan faktor koagulasi yang berperan penting dalam meningkatkan keparahan penyakit dan kematian.
Tujuan. Penelitian ini bertujuan untuk menyelidiki hubungan antara gangguan faktor koagulasi dan tingkat keparahan infeksi dengue pada anak.
Metode. Tinjauan retrospektif dilakukan pada rekam medis anak-anak di bawah 18 tahun yang dirawat dengan infeksi dengue dari Januari 2020 hingga Desember 2022 di Rumah Sakit Umum Pusat Prof. Dr. R. D. Kandou, Manado. Keparahan infeksi dengue diklasifikasikan berdasarkan kriteria WHO 2011, mulai dari demam dengue hingga DHF grade IV. Hubungan antara gangguan koagulasi dan keparahan infeksi dengue dianalisis menggunakan uji point biserial dengan ? <0,05 dan power 0,80.
Hasil. Dari 182 anak dengan infeksi dengue, peningkatan proporsi elongasi prothrombin time (PT), activated partial thromboplastin time (aPTT), dan international normalized ratio (INR) ditemukan seiring peningkatan keparahan DHF. Hubungan signifikan ditemukan pada PT (r=0,309, p<0,001), aPTT (r=0,356, p<0,001), dan INR (r=0,233, p=0,002).
Kesimpulan. Penelitian ini menyimpulkan adanya hubungan signifikan antara gangguan faktor koagulasi dan tingkat keparahan dengue pada anak-anak, yang berpotensi muncul sejak tahap awal infeksi.
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DOI: http://dx.doi.org/10.14238/sp26.6.2025.337-42
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