Korelasi Kadar Hemoglobin dengan Kadar Vascular Endothelial Growth Factor Plasma pada Tetralogi Fallot
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Latar belakang. Vascular endothelial growth factor-A (VEGF-A) diketahui merupakan penanda hipoksia jaringan yang berperan dalam angiogenesis. Anak dengan penyakit jantung bawaan sianotik seperti Tetralogi Fallot (TF) mengalami hipoksia jaringan dengan komplikasi timbulnya pembuluh darah baru kolateral, polisitemia hipoksik, dan anemia relatif.
Tujuan. Menentukan korelasi kadar VEGF plasma dengan kadar Hb.
Metode. Penelitian analisis cross-sectional yang mengambil data secara konsekutif anak TF yang berobat ke poli rawat jalan dan rawat inap Departemen Ilmu Kesehatan Anak Rumah Sakit Dr. Hasan Sadikin, Bandung. Kekuatan korelasi kadar Hb dengan VEGF ditentukan dengan uji korelasi Spearman. Kemaknaan dihitung berdasarkan nilai p<0,05. Analisis data dilakukan dengan program SPSS for windows versi 17.0.
Hasil. Duapuluh pasien anak TF yang menjadi subjek penelitian, terdiri atas 9 anak laki-laki dan 11 anak perempuan. Didapatkan korelasi negatif bermakna berkekuatan sedang antara kadar Hb dan kadar VEGF (r=-0,503; p=0,024). Tidak terdapat perbedaan bermakna kadar VEGF plasma menurut jenis kelamin dan status gizi (p=0,412 dan 0,948), tetapi terdapat perbedaan bermakna kadar VEGF plasma menurut kelompok usia (p=0,048).
Kesimpulan. Terdapat korelasi negatif antara kadar Hb dan kadar VEGF plasma. Kadar VEGF plasma dapat diperkirakan dari kadar Hb, apabila kadar Hb semakin rendah, maka kadar VEGF meningkat.
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Breitbart RE, Flyer DC. Tetralogy of fallot. Dalam: Keane JF, Lock JE, Flyer DC, penyunting. Nadas’ pediatric cardiology. Edisi ke-2. Philadelphia: Elsevier-Saunders; 2006.h.559-80.
Bailliard F, Anderson RH. Review: tetralogy of fallot. Orphanet J Rare Dis. 2009 [diunduh 12 September 2010]. Didapat dari: BioMed Central. http://www.ojrd.com/
Apitz C, Anderson RH, Redington AN. Tetralogy of fallot with pulmonary stenosis. Dalam: Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, penyunting. Pediatric cardiology. Edisi ke-3.Philadelphia: Elsevier; 2010.h.753-73.
Park MK. Pediatric cardiology for practitioners. Edisi ke-5. Philadelphia: Mosby Elsevier; 2008.
Webb GD, Smallhorn JF, Therrien J, Redington AN. Disease of the heart, pericardium, and pulmonary vasculature bed. Dalam: Libby P, Bonow RO, Mann DL, Zipes DP, penyunting. Braunwald’s heart disease; a textbook of cardiovascular medicine. Edisi ke-8. Philadelphia: Elsevier; 2008.h.1561-624.
Dor Y, Porat R, Keshet E. Vascular endothelial growth factor and vascular adjustments to pertubations in oxygen homeostasis. Am J Physiol Cell Physiol 2001;280:1367-74.
Ferrara N, Smyth TD. The biology of vascular endothelial growth factor. Endocrine Rev 1997;18:4-25.
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocrine Rev 2004;25: 581-611.
Tschirch E, Weber B, Koehne P, Guthman F, Gise AV, Wauer RR, dkk. Vascular endothelial growth factor as a marker for tissue hypoxia and transfusion need in anemic infant: a prospective clinical study. Pediatrics 2009;123:784-90.
Baghdady YMK, Mohamed S. Vascular endothelial growth factor in children with cyanotic and acyanotic congenital heart disease. Heart Mirror J 2008;2:24-7.
Ootaki Y, Yamaguchi M, Yoshimura N, Oka S, Yoshida M, Hasegawa T. Vascular endothelial growth factor in children with congenital heart disease. Ann Thorac Surg 2003;75:1523-6.
Suda K, Matsumura M, Miyanish S, Uehara K, Sugita T, Matsumoto M. Increased vascular endothelial growth factor in patients with cyanotic congenital heart disease may not be normalized after Fontan type operation. Ann Thorac Surg 2004;78:942-6.
Tolunay I, Tunauglu S, Akyurek N, Halid V, Olgunturk R, Kula S. Serum and pulmonary vascular endothelial growth factor/receptors and haemodynamic measurements in cyanotic congenital heart disease with decreased pulmonary blood flow. Cardiol Young 2011;21:608-15.
Melegy NTE, Mohamed NA. Angiogenic biomarkers in children with congenital heart disease: possible implications. Italian J Pediatr 2010;36:32.
Himeno W. Angiogenic growth factors in patients with cyanotic congenital heart disease and in normal children. Kurume Med J 2001;48:111-6.
Lassus P, Ristimaki AT, Ylikorlala O, Anderson S. Vascular endothelial growth factor in human preterm lung. Am Respir Cret Care Med 1999;159:1429-33.
Amstrong FJ, Bischoff J. Heart valve development: endothelial signaling and differentiation. Circ Res 2004;95:459-70.
Akker NMS, Molin DGM, Peters PPWM, Maas S, Wisse LJ, Brempt R, dkk. Tetralogy of fallot and alteration in vascular endothelial growth factor-A signaling and notch signaling in mouse embryo solely expressing the VEGF120 isoform. Circulation Research 2007;100:842-9.
Lambrecths D, Devriendt K, Driscoll DA, Goldmuntz E, Gewilig M, Vlietinck R, dkk. Low expression VEGF haplotype increase the risk for tetralogy of fallot: a family based association study. J Med Genet 2005;42:519-22.
Griffin HR, Hall DH, Topf A, Eden J, Stuart G, Parson J,, dkk. Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. Plos One J 2009;4:e4978.
Andrews NC. Iron deficiency and related disorders. Dalam: Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN, penyunting. Wintrobe’s clinical hematology. Edisi ke-11. Philadelphia: Lippincott Williams & Wilkins; 2004.h.969-1009.
Siwik ES, Erenberg F, Zahka KG, Goldmuntz E. Tetralogy of fallot. Dalam: Allen HD, Driscoll DJ, Shaddy RE, Feltes TS, penyunting. Moss and adams’ heart disease in infant, children and adolescent, including fetus and younf adult. Edisi ke-7. Volume 2. Philadelphia: Lippincott Williams & Wilkins; 2007.h.889-910.
DOI: http://dx.doi.org/10.14238/sp15.3.2013.156-60
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